Going South on I-65, take Exit 326 (Highway 36). Turn right onto Highway 36. Follow Highway 36 through town. Highway 36 is also Main Street. Go to Sparkman Street. Turn left. Follow Sparkman Street until you see Hartselle High School on the left.

Going North on I-65, take Exit 325 (Thompson Road). Turn left onto Thompson Road (you will go over interstate). Follow Thompson Road to Highway 31. Turn right onto Highway 31 (you will be going North on 31). Go to first traffic light. Turn right on Sparkman Street. Follow Sparkman Street until you see Hartselle High School on the right.

From Moulton, take Highway 157 to Highway 36.  Go east on Highway 36 to Hartselle.  Highway 36 will turn into Main Street.  After crossing, Highway 31 go to Sparkman Street.  Turn right onto Sparkman Street.  Follow Sparkman Street until you see the Hartselle High School on the left.